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Podcast: Research To Practice | Oncology Videos
Episode: Paroxysmal Nocturnal Hemoglobinuria | Oncology Today with Dr Neil Love: Management of Paroxysmal Nocturnal Hemoglobinuria
Description: Featuring perspectives from Dr Carlos M de Castro, including the following topics: Biology of paroxysmal nocturnal hemoglobinuria (PNH) (0:00) Evolution of the PNH treatment landscape (13:07) Selection and sequencing of therapies for patients with PNH (18:09) Overview and presentation of extravascular hemolysis (23:50) Case:Â A woman in her early 40s with PNH who developed Budd-Chiari syndrome and had an excellent response to C5 inhibition (26:57) Case: A woman in her early 40s with a suboptimal response to ecluizumab followed by an excellent response to pegcetacoplan on the PEGASUS trial (34:00) Case: A woman in her mid 40s who experienced breakthrough hemolysis with pegcetacoplan and w...