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Podcast: RunAs Radio
Episode: Eric Shupps Improves SharePoint Performance!
Description: Richard chats with Eric Shupps about the process of improving SharePoint performance. Starting with the single-server implementation of SharePoint, Eric walks through each point of tuning SharePoint including database tuning, separating web front ends from application servers, separating off services, etc. Microsoft has a great site on Best Practices for SharePoint Server 2010.