Want to create an interactive transcript for this episode?
Podcast: The Mental Elf
Episode: Grainne McAlonan #IoPPNfestival
Description: Prof Grainne McAlonan, Professor of Translational Neuroscience in the Department of Forensic and Neurodevelopmental Sciences at King's College London.Synopsis: Autism Spectrum Disorder (ASD) is clinically diverse, and its etiological mechanisms are poorly understood. To inform prognosis and generate intervention opportunities we need a better understanding of causal pathways; and subsequently, a means to examine target engagement. There is fresh hope however, based on evidence that multiple risk factors for ASD and related neurodevelopmental conditions converge to disrupt the balance between excitatory glutamate (E) and inhibitory GABA (I). This will likely alter the activity and structure of brain circuits which...