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Podcast: Real Life Pharmacology - Pharmacology Education for Health Care Professionals
Episode: Primidone Pharmacology
Description: On this episode, I discuss primidone pharmacology, adverse effects, and drug interactions.
Primidone, or Mysoline, is an anticonvulsant most commonly used for essential tremors. The primary pharmacological mechanism of action of primidone is similar to other anticonvulsants, like phenobarbital. It causes a reduction in the activity of neurons. Both primidone and its metabolites are potent anticonvulsants. Primidone alters the transmembrane Na/Cl transport channel to reduce the frequency of nerve firing. Phenobarbital, one of primidone’s active metabolites, interacts with GABA-A receptors and chloride channels to reduce nerve excitability.  Â
Typically B-blockers are used first for essen...