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Podcast: Real Life Pharmacology - Pharmacology Education for Health Care Professionals
Episode: Glipizide Pharmacology
Description: Glipizide, or Glucotrol, is a sulfonylurea used for the treatment of Type 2 Diabetes. Pharmacologically, glipizide acts by stimulating beta-cells in the pancreas to release insulin. Specifically, glipizide will block the opening of ATP-sensitive potassium channels on the plasma membrane of beta-cells on the pancreas. The result of that is depolarization, which then causes stimulation of voltage-sensitive calcium channels, eventually causing the exocytosis of insulin. The increased insulin will then promote the storage of glucose, decreasing the amount of glucose in the blood.Â
Due to the pharmacology of glipizide, the concerning adverse drug reactions are hypoglycemia and weight g...