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Podcast: BioPOD
Episode: How to Characterize the Structure of Lamin-A Proteins in Cells with Dr Alex Makarov
Description: Episode 5: Dr Alex Makarov In this episode, Chris sits down with Dr Alex Makarov who recently completed a PhD in Eric Schirmer's lab in the Wellcome Centre for Cell Biology at the University of Edinburgh. His research focused on Lamin A proteins, an important structural protein which gives cells their flexibility and shape. Dr Makarov recently published his novel work on the alternative methods to characterise the structure of flexible Lamin A proteins, namely SILAC cross-linking mass spectrometry. Lamin-A function is so important that mutations leading to alterations of this protein's structure are linked to 13 distinct hu...