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Podcast: Surfing the MASH Tsunami
Episode: S4-E23.3 - Lowering Screen Fail Rates and Guidelines for the Biopsy Reading Process
Description: Stephen Harrison joins Louise Campbell and Roger Green for an insight-laden episode about challenges and opportunities in NASH drug development. This conversation continues from the preceding discussion on screen fail rates. Louise starts by asking what would the ideal patient look like for an attempt at lowering screen fail rates. Stephen responds with two assertions. The first suggestion is that higher hemoglobin A1C is indicative of disease activity in the fibrosis needed to qualify. Second, Stephen identifies utility in retrieving a FibroScan-AST score as a promising prescreen strategy. From here the conversation considers the variability of liver biopsy...