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Podcast: Surfing the MASH Tsunami
Episode: S3-E38.7 - From the Vault: How Ballooned hepatocyte Reads Affect NASH Clinical Trials
Description: Our week of "Greatest Hits" episodes from the vault continues with this conversation from the episode discussing systematic failures of NAS scoring due to inconsistencies in how different pathologists interpret slides. This conversation explores the reasons for different histopathologists differing consistently in how they interpret liver slides.One of the primary drivers of reassessing the role of semi-quantitative histopathology in assessing developmental drugs was the paper "Complexity of ballooned hepatocyte feature recognition: Defining a training atlas for artificial intelligence-based imaging in NAFLD," e-published in January 2022 in the Journal of Hepatology. This paper demonstrated strong systematic flaws in...