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Podcast: Surfing the MASH Tsunami
Episode: S3-E26 - What Are We Learning About Clinical Trial Best Practices For NITs?
Description: Quentin Anstee joins Stephen Harrison, Jörn Schattenberg, Louise Campbell and Roger Green to share recently developed insights about NITs and what the clinical trial best practices around them should be. Quentin started by offer five key takeaways from his recent talks at The Liver Forum and ICFL in Vienna:(1) As we have discussed on this podcast and elsewhere, trial endpoints around balloon hepatocytes are, in Quentin's words, "not sufficiently robust." (2) Rapidly attaining response from a given test (ALT, for example) is not necessarily a guarantee of early efficacy. (3) "Simple indirect biomarker panels like FIB-4" nee...