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Podcast: Surfing the MASH Tsunami
Episode: S3-E17.1 - Potential Breakthrough in Anti-Fibrotic Therapies Through mRNA/CAR-T Combined Therapies
Description: Professors Scott Friedman and Neil Henderson join the Surfers (including the returning Stephen Harrison) to discuss some truly exciting advances in the basic science and technology of defining, diagnosing and treating NAFLD and NASH. This conversation focuses largely on mRNA/CAR-T anti-fibrotic therapies.Scott Friedman starts this conversation by reviewing the historical sequence that led to the development of an mRNA vaccine that can create CAR-T cells in mice for the express purposes of attacking fibrotic tissue.Originally, CAR-T was developed to create cells that kill certain lymphomas. In the original design, white cells were...