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Podcast: Surfing the MASH Tsunami
Episode: S3-E16.4 - What a Disease Model Suggests about the NASH Diagnostic Path
Description: This conversation starts by focusing on issues related to diagnostic testing and what we attempt to detect or prove with each test. It starts with Roger Green noting the challenge of widespread population testing for fast progressors: the easy, inexpensive test for widespread 1st-line population testing is FIB-4, but FIB-4's lack of positive predictive value makes it a poor test for assessing this question, besides which, as Alina Allen notes, FIB-4 will increase with age.Chris Estes comments that modeling costs of a given approach must not only take into account the actual cost of an...