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Podcast: Surfing the MASH Tsunami
Episode: S3-E16.2 - What a NASH Disease Model Reveals About Treating Advanced Fibrosis
Description: This conversation starts with Chris Estes describing the processes he and his colleagues at the Center for Disease Analysis Foundation have used to build a disease model for NAFLD and NASH prevalence in 15 countries. Chris discusses some of the unique challenges that modeling NASH presents. Among other items, these include (a) spontaneous regression of disease; (b) "excess" mortality (mortality not from liver disease where NASH is a contributing factor); and (c) interplay of demographics (gender, age, race, etc.) and co-morbidities (most notably Type 2 diabetes) with disease.When Chris ends his initial comments, Jörn Schattenberg asks about t...