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Podcast: Surfing the MASH Tsunami
Episode: S3-E14.3 - Systematic Flaws in Semi-Quantitative Ballooned Hepatocyte Analysis
Description: One major discussion at NASH-TAG this year was about the inconsistency in ballooned hepatocyte identification and how this inconsistency inflates screen fail rates and possibly placebo response across studies. This conversation is part of a thorough exploration of this issue.This conversation starts with Roger Green asking Stephen Harrison how clinical trial analysis might change for the better pending implementation of what researchers learned in this study. Stephen suggests that the area in greatest need of improvement is efficacy analysis at the back end of clinical trials. Specifically Stephen notes that variability in placebo response rates is...