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Podcast: Surfing the MASH Tsunami
Episode: S3-E14.2 - Can We Manage Statistical Error in Ballooned Hepatocyte Analysis Better?
Description: One major discussion at NASH-TAG this year was about the inconsistency in ballooned hepatocyte identification and how this inconsistency inflates screen fail rates and possibly placebo response across studies.This conversation is part of a thorough exploration of this issue. It starts with Mazen Noureddin raising two questions about the entire subject of ballooned hepatocyte scoring in NAS assessment: should we use it at all, and if we should, should we move immediately to AI as the key to analysis?Quentin provides nuanced answers to both questions. On the issue of ballooned hepatocytes, he notes...