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Podcast: Surfing the MASH Tsunami
Episode: S3-E14.1 - How Ballooned Hepatocyte Analytics Weaken NASH Clinical Trials
Description: One major discussion at NASH-TAG this year was about the inconsistency in ballooned hepatocyte identification and how this inconsistency inflates screen fail rates and possibly placebo response across studies.This conversation explores that issue in detail. It begins with Quentin Anstee eloquently laying out the challenge that led to this study and the approach it took.The challenge: recent studies have produce Kappa values for coding NAS scores in the 0.55 - 0.60 range. These scores suggests a level of error-related noise that might swamp a signal that a drug actually works.The solution: nine of...