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Podcast: CME
Episode: Is it Nonresponsive/Progressive ISM?
Description:
Host: Nathan A. Boggs, MD
Host: Tracy George, MD
Host: Lindsay Rein, MD
The identification of KIT D816V mutation as a key driver for the expansion and accumulation of neoplastic mast cells in systemic mastocytosis (SM) has significantly improved the diagnosis, subclassification, and management of SM. Moreover, the advent of novel targeted therapies has dramatically changed the treatment landscape. However, challenges persist for community clinicians due to the low prevalence of SM and its vague and wide spectrum of clinical features. Expanded knowledge of the recommended pathology and laboratory evaluation for the diagnosis and subclassification...