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Podcast: Inside Startup Investing with Chris Lustrino
Episode: Re-Programming Viruses to Fight Brain TumorsāInside Siren Biotechnology
Description: On this weekās Inside Startup Investing, Dr. Nicole Paulkāfounder & CEO of Siren Biotechnologyādetails her AAV gene-therapy āFedEx truckā that can deliver anti-tumor cytokines directly to brain cancers. Early animal data show 86 % complete responses; the FDA has signaled a fast-track path for Sirenās first-in-human trial set for 2026. With analog comps like Keytruda earning $30 B a year, Sirenās upsideāand impactācould be enormous.Highlights include...Why viruses? AAV viruses donāt cause disease in humans yet efficiently deliver genetic payloads; Siren re-engineers them to express anti-tumor cytokines.Twin āfirsts.ā Siren pursues the first AAV-based cancer t...