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Podcast: Real Life Pharmacology - Pharmacology Education for Health Care Professionals
Episode: Piperacillin/Tazobactam Pharmacology
Description: Zosyn (piperacillin/tazobactam) is a broad-spectrum Ξ²-lactam/Ξ²-lactamase inhibitor combination used widely in hospitals. Piperacillin covers gram-positive, gram-negative, and anaerobic bacteria, while tazobactam helps protect against Ξ²-lactamase breakdown. It is commonly used for pneumonia, intra-abdominal infections, skin and soft tissue infections, and febrile neutropenia. An important pharmacology pearl for exams is understanding that Pseudomonas, but it doesnβt cover MRSA.
The drug is renally eliminated, so dosing adjustments are needed in kidney impairment. Many institutions use extended or prolonged infusions to maximize time above the MIC, which can improve efficacy. Standard dosing is 3.375 g to 4.5 g every 6β8 hours...