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Authentic Biochemistry

Become a Paid Subscriber: https://anchor.fm/dr-daniel-j-guerra/subscribe Become a Paid Subscriber: https://anchor.fm/dr-daniel-j-guerra/subscribe You have wisely landed upon Authentic Biochemistry, with Dr. Daniel J Guerra, where published biochemical, physiological, genetic and immunological research along with biomedical and pharmaceutical science are interrogated.

BioMedical Portrait III. c.4. Adipose tissue macrophages express galectin binding proteins which alter immunosuppression and polarization;adipokines mediate the inflammatory response. DJGPhD.17.9.23

29 mins; September 17, 2023

BioMedical Portrait III. Immunometabolic disease 3c.Reactive N and O interconversions in obese adipose exacerbate systemic inflammation. 17.9.23. DJGPhD. Authentic Biochemistry Podcast.

29 mins; September 17, 2023

BioMedical Portrait III. Immunometabolic disease. The obesity-compromised adipose poise to hyperinflammation. DJGPhD. 15.9.23. Authentic Biochemistry.

30 mins; September 15, 2023

BioMedical Portrait III. c1. Immuno-metabolic disease. Dr. Daniel J. Guerra. 14.9.23. Authentic Biochemistry Podcast.

30 mins; September 14, 2023

Biochemical Energetics. Elementary Considerations chapter2. DJGPhD. 13.9.23 Authentic Biochemistry Podcast

29 mins; September 13, 2023

Biochemical Energetics I Elementary Considerations. DJGPhD 12Sept23. Authentic Biochemistry Podcast.

30 mins; September 12, 2023

BioMedical Portrait II. Hashimoto's Thyroiditis prevalence in women linked to mitochondrial electron transport chain activity, ATP/ADP translocation, and potent autoantibodies to thyroid peroxidase.

30 mins; September 10, 2023

BioMedical Portrait II. c.14. Predominance of Hashimoto's Thyroiditis in Women: is there a link to the decreased expression of TLR7 and the AMPK-alpha/Id3 axis on CD8+TE and Treg activity?

29 mins; September 10, 2023

BioMedical PortraitII. c13. Female prevalent autoimmune RA-macrophage STAT3(TF) and NaMPT(NAD+ salvage pathway) promote rheumatoid arthritis & primer on thyroiditis

30 mins; September 08, 2023

BioMedical Portrait II. C12. Lupus is far more common in women than men due to TLR7 enhancement and Rheumatoid Arthritis is more common in women due to macrophage bioeneregtic phenomenaDJGPhD.7Sept23

30 mins; September 07, 2023

BioMedical Portrait II.c11. Autoimmune diseases like lupus are far more prevalent in women due to the lack of X chromosomal allelic inactivationof TLR7's. DJGPhD.7Sept23.Authentic Biochemistry.

30 mins; September 07, 2023

Biomedical Portrait!!,c.10 Older women have more reactive oxygen and fewer functional mitochondria and DNA content than older men or younger women.DJGPhD.5Dept2023. Authentic Biochemistry Podcast.

30 mins; September 05, 2023

BioMedical Portrait II. c9. Autoimmune diseases are more common in women than men: immune response triggering and the possible role of bioenergetics.DJGPhD.3sept23.Authentic Biochemistry.

29 mins; September 03, 2023

BioMedical Portrait II. C.8. Alterations in sphingosine metabolism linked to breast cancer staging in women and progression of NAFLD to NASH and HCC is much lower in women until menopause.DJGPhD.

30 mins; September 02, 2023

Biomedical Portrait II. C.7. Serum sphingolipid molecular speciation in women differs from men but association with tissue endomembranous lipid components fail to be addressed.DJGPhD. 31.8.23

29 mins; August 31, 2023

BioMedical Portrait II. Metabolic and Bioenergetic distinction between men and women includes lipid deposition and utilization mechanisms.DJGPhD.30.8.23.Authentic Biochemistry Podcast.

29 mins; August 30, 2023

BioMedical Portrait II, c.5. Muscle fibre sexual dimorphism obtains networks of genetic, epigenetic, and biochemical events.DJGPhD.29.8.23 Authentic Biochemistry Podcast

29 mins; August 29, 2023

Biomedical PortraitII.C.4 THe sexual dimorphism of bioenergetics: introduction to carbon utilization. Video lecture link

1 min; August 28, 2023

BioMedical Portrait II. Chapter 3. Mitochondrial gene expression, lipid metabolism and cell fate are at least partiatially mediated by Fragile X protein competency. DJGPhD.24.8.23

30 mins; August 24, 2023

BioMedical Portrait II. The Fragile X Syndrome. Discovery and subsequent association with the FMR1 gene. Premature Ovary Failure I vs. heritable intellectual disabilities DJGPhD.22.8.23

30 mins; August 22, 2023

BioMedical Portrait II.Diseases of Bioenergetics:Male vs. Female Variation

29 mins; August 21, 2023

BioMedical Portrait I. 13b. 25 hydroxy cholesterol controling SREBP is linked toinflammation and the regulation of potentiating estrogen mediation over AD in post menapausal women.DJGPHD.18.8.23

30 mins; August 18, 2023

Biomedical Portrait I, 13. Receptor boud 17Beta-estradiol may overturn the the failure to synthesize cholesterol in CNS caveolae thus blocking release of Beta-secretase to generate A-beta from APP.

29 mins; August 18, 2023

BioMedical Portraits I. Chapter 12. Unique lipoprotein lipase mediated lipid alteration of endothelial cell function in the mammalian CNS may traffick in oxysterol binding protein linked PM-female AD

29 mins; August 17, 2023

BioMedical Portraits I. [11]. Phospholipid and lipoprotein lipase activity may link to oxy-cholesterol/PL transport mechanisms to generate post-menopausal AD. DJGPhD.16.8.23. Authentic Biochemistry

30 mins; August 16, 2023

BioMedical PortraitI-10. Sterol binding protein and oxysterols regulate membrane fusion and trafficking obtaining a complex landscape for post menopausal estrogen assoc. neurodegeneration.DJGPhD.

30 mins; August 14, 2023

BioMedical PortraitsI.9. The 27-hydroxychol association with estrogen receptors and LXR provide contrarion associations with female AD and immune-controlled bacterial pathophysiology.DJGPhD.14.8.23

28 mins; August 14, 2023

BioMedical Portrait I. Chapter 8. Female AD progression post-menopausal severity is a complex pathobiochemical event that may involve cholesterol and steroid metabolism in the CNS and periphery.DJGPhD

29 mins; August 12, 2023

BioMedical Portraits I. Chapter 7. Hormone replacement and the general distinctions of cholesterol homeostasis, metabolic zonation, hydroxysterols and estrogen receptor heterogeneity in female AD.

29 mins; August 11, 2023

BioMedical Portraits I. Chapter 6. Complications of female cerebrovascular trauma and obesity-linked Type2 Diabetes in post-menopausal estrogen therapeutics for prophylactic treatment of subsequent AD

29 mins; August 09, 2023

Biomedical Portraits I. Part 5. 17-beta estradiol monotherapy in post-menopausal women has no irrefutable therapeutic benefit for treating cognitive decline in early AD dementia.DJGPhD.8AUG23.AB.

29 mins; August 07, 2023

BioMedical Portraits I. Part 4 Loss of female gonadal E2 production plus CNS E2 Receptor expression post-menopause involves irreversible alterations in metabolism:implications for neuroprotection.

29 mins; August 06, 2023

BioMedical Portraits I. part 3 Estrogen receptor heterogeneity in signaling and transcription and the distinctions between model-murine and human reproductive and CNS biochemistry.DJGPhD 05AUG23

29 mins; August 05, 2023

BioMedical Portraits I. Part 2.Murine model Alzheimer's Disease is poorly linked to menopuase or Vascular contributions to Cognitive Impairment & Dementia (VCID).DJGPhD 05AUG23

30 mins; August 05, 2023

BioMedical Portraits I. Alzheimers Disease in Ageing Females is linked to CNS-sphingomyelinase mediated ketogenesis and VCID.Lecture 1. DJGPhD.3AUG23.Authentic Biochemistry

30 mins; August 03, 2023

From Intellections' pathway into the forest of metaphysics.II DJGPhD.30.July 2023b. Authentic Biochemistry Podcast

29 mins; July 30, 2023

The Road to Intellection I. DJGPhD. 30.7.23. Authentic Biochemistry Podcast

30 mins; July 30, 2023

ImmunoEpigenetics 100B. Fine. The apodictic recombination-dependent TCR and Ig receptor system is mediated by epigentic modifications.DJGPhD.29.7.23. Authentic Biochemistry

29 mins; July 29, 2023

ImmunoEpigenetics100A. The Tcell repose and ILC differentiation via E vs ID chromatin remodeling antagonism. DJGPhD.28.7.23. Authentic Biochemistry Podcast.

30 mins; July 28, 2023

ImmunoEpigenetics 99. Tregs can foster a massive tumor microenvironment inhibition of T-eff cell populations via neo-antigen activation from dying tumor cells leading to cancer progression. DJGPhD

29 mins; July 26, 2023

ImmunoEpigenetics 98. TCR mediated protection from neonate infection is naturally suppressed. BCG VAX may be a treatment against Type 1 Diabetes by increasing Treg mediated autoimmune suppression.

29 mins; July 25, 2023

ImmunoEpigenetics97.Bcell maturation involves a multilevel epigenetic mark-up of differentiating pathways to subsequently respond to T cell activation upon 2nd signal stimulation. DJGPhD.24.7.23

29 mins; July 24, 2023

ImmunoEpigenetics96. APC-agMHCII and Bcell:Tcell synapse interactions yield subsequent plasma cell antibody production under the H3K4me3 epigenetic alteration of chromatin accessibility.DJGPhD.23.7.23

29 mins; July 23, 2023

Mountain Pass Adventure I. The "five best" and an excursion into asymmetry. Dr. Daniel J. Guerra. 22.7.23. Authentic Biochemistry Podcast.

29 mins; July 22, 2023

ImmunoEpigenetics 95. Does H3K4 trimethylation play a quantitative or qualitative role in nascent activation of neonatal naive T cells toward a specific polarity of gene expression?DJGPhD.20.7.23

29 mins; July 20, 2023

ImmunoEpigenetics. 94. Neonate TCR stimulation and subsequent signaling circumventing TCR specificity differ from adult activation and cytokine expression. DJGPhD. 19.7.23. Authentic Biochemistry

28 mins; July 19, 2023

ImmunoEpigenetics 93. tTREG's not only control Th differentiation and proliferation but in an HLA-antigen mediated specificity thus differentiating CD4+ vs CD8+ inflammation as directed by 6mA.

30 mins; July 18, 2023

ImmunoEpigenetics 92. thymic Treg populations alter Th1 differentiation. Antigen presenting DC's coordinate TCR with associated membrane proteins to support activation via PM lipid sequence.DJGPhD.

30 mins; July 17, 2023

ImmunoEpigenetics91. WTAP conditional deletion via LoxPCre controlled by FoxP3 obtains a Treg phenotype incapable of supressing murine spontaneous colitis. DJGPhD. 15.7.23. Authentic Biochemistry.

29 mins; July 15, 2023

ImmunoEpigenetics90. Tcell receptor organization activation and adaptor protein ligand molecular signaling is regulated down stream by 6methyl mRNA speciation.DJGPhD.7July2023.Authentic Biochemistry

29 mins; July 11, 2023

Enzyme Kinetics sensu strictu. The Michaelis Menten equations and precison of the kcat. DJGPhD.9July23b. Authentic Biochemistry Podcast.

29 mins; July 09, 2023

Primer on enzyme kinetics in clinical biochemical research. DR. Daniel J. Guerra. 09July2023. Authentic Biochemistry Podcast Productions

30 mins; July 09, 2023

PhotosynthesisV. Photorespiration and synthesis of this holiday arc: fait accompli. DJGPhD.08July23b. Authentic BiochemistryPodcast.

29 mins; July 08, 2023

Photosynthesis 4. Chlorophyll and carotene biosynthesis and some further detail on the mechanism of the Mn-H20 splitting complex of p680 PSII and diatomic molecular oxygen (O2) evolution.DJGPhD. 7July

30 mins; July 08, 2023

Photosynthesis 3. Dr Daniel J Guerra. 07July2023 Authentic Biochemistry Podcast productions

29 mins; July 06, 2023

Unique Lecture Post holidayIV. Photosynthesis 2. DJGPhD.05July23b Authentic Biochemistry Podcast production.

30 mins; July 05, 2023

Unique Lecture Series Post holiday. III Higher plant photosynthesis 1. DJGPhD. 05July2023. Authentic Biochemistry Podcast.

30 mins; July 05, 2023

Unique Lecture Series Holiday Time 4th of July2023.Non-arbitrary C-C bond formation chemistry: Aldol and Claisen condensation with Stork enamine synthesis (i.e. Michael reactions)

29 mins; July 03, 2023

Unique Lecture Series . Holiday Time. 4th of July 2023! Hydrocarbons.

30 mins; July 01, 2023

ImmunoEpigenetics 89. Final synthesis of statin drug mediated alteration of metabolism in T lymphocytes. DJGPhD.6.30.23. Authentic Biochemistry Podcast.

29 mins; June 30, 2023

ImmunoEpigenetics 88. Statin treatment of early progenitor T cell acute lymphoblastic leukemia could pose biochemical impositions on healthy lymphocyte populations. DJGPhD.29.6.23.Authentic Biochem.

29 mins; June 29, 2023

ImmunoEpigenetics87. Competitive inhibition of HMGCoA-R may enhance apoptosis while blocking cholesterologenesis and GGPP covalent modification of signaling kinases to thwart ETP-All in cell culture.

29 mins; June 28, 2023

ImmunoEpigenetics86. Could regimented titrating statin pharmacotherapy be useful in controlling early T lymphoid progenitor cell ETP-ALL via an epigenetic mechansim? DJGPhD.27.6.23. Authentic Biochem

28 mins; June 27, 2023

ImmunoEpigenetics85.Epigenetic plasticity-induced chromatin retailoring involving the mevalonic acid -prenyl lipid pathway promotes Early T-cell Precursor Acute Lymphoblastic Leukemia. DJGPhD.24.6.23

28 mins; June 24, 2023

ImmunoEpigenetics84. T cell and ILC transcription factor and cytokine signaling coordination to accelerate a combined innate/acquired immune response requires discrete epigenetic programming. DJGPhD.

29 mins; June 23, 2023

ImmunoEpigenetics 83. Epistemic and metaphysical considerations of immune cell epigenetic reprogramming obtaining biochemical event ontologies. DJGPhD.23.6.23. Authentic Biochemistry Podcast

30 mins; June 23, 2023

ImmunoEpigenetics82.Innate lymphoid progenitor antibody-directed single cell DNAse hypersenitive site analysis of transcription factor specific histone methylation and acetylation modifications.DJGPhD

29 mins; June 22, 2023

ImmunoEpigenetics 81.Innate lymphoid cells lack antigen receptors and are differentiated into multiple linneages via epigenetic priming of nucleosomal regions proximal to cell-specific TF's.DJGPhD.

30 mins; June 21, 2023

ImmunoEpigenetics80.T lymphocyte biochemical communications are triggered epigentically and via membrane lipid molecular species recombination: A dialectical event ontological view. DJGPhD.17.6.23

30 mins; June 17, 2023

ImmunoEpigenetics79. T lymphocyte DPPA induced HSP27 deoligomerization-activating DGK-a associated anergy is linked to cancer cell proliferation phenotypes. DJGPhD.16.6.23b Authentic Biochemistry

29 mins; June 16, 2023

ImmunoEpigenetics 78. Classical ergodic forward deterministics do not explain biological systems; biochemical phenomena are tuned for uncertain events. DJGPhD.16.6.23. Authentic Biochemistry Podcast

29 mins; June 16, 2023

ImmunoEpigenetics77. T cell membrane phospholipase D mediated PA deprotonation as a biosensor for an electrostatic/hydrogen-bond signal transductionDJGPhD.15.6.23. Authentic Biochemistry Podcast.

28 mins; June 15, 2023

Interum lecture VI. Entropic forces and the ergodic hierarchy of GPCR-linked phsopholipase phase space postioning temporality. DJGPhD.13.6.23

29 mins; June 13, 2023

Interum Lecture V. Semi-closure on free energy and enthalpic involvement in leptin/AMPK mediated orexigenic states . DJGPhD.12June23.Authentic Biochemistry Podcast

29 mins; June 12, 2023

Interum Lecture IV. MBD:DNAMolecular Dynamics video lecture!

1 min; June 11, 2023

Interum Lecture III. Protein methylation binding domain association with substrate CpG alters equilibrium torsion angle (epsilon-zeta) conformational states via enthalpic-free energy conservation.

29 mins; June 10, 2023

Interum Lecture II. Rates of reactions in living systems.DJGPhD.8June2023 Authentic Biochemistry Podcast

30 mins; June 08, 2023

Interrum lecture I. Obesity unsuccessfully violates the first law of thermodynamics.

30 mins; June 07, 2023

ImmunoEpigenetics 76. Sphingolipid metabolism and S1P receptor expression linked to multiple potentiating immunoinflammatory obese associated pathophysiologies. DJGPhD.6June23B AuthenticBiochemistry

29 mins; June 06, 2023

ImmunoEpigenetics 75. Sphingolipid receptor molecular discernment from exosome cargo mediated control involves M1 to M2 polarization shift post myocardial infarction induced fibrosis. DJGPhD.6June23

30 mins; June 06, 2023

ImmunoEpigenetics74.The methylation-specific epigenetic control over adipose tissue macrophage polarity is axially supported by leptin induced CNS control over satiety and pancreatic insulin secretion

30 mins; June 05, 2023

ImmunoEpigenetics 73. The dialectical synthesis of adipose PPAR-gamma mediated fatty acid binding protein4 expression in foam cell formation and subsequent adipokine contribution to insulin secretion

29 mins; June 04, 2023

ImmunoEpigenetics72. Chemistry of reactive oxygen/nitrogen radical species as adipose pathobiochemical sequalae to obesity via M1 macrophage polarity involving adipose and vasculature pathophysiology.

29 mins; June 02, 2023

ImmunoEpigenetics 71. Insulin receptor corruption is mediated by high circulating fatty acids, in situ DAG-PKCepsilon induced phosphorylation and membrane protein aggregation in obese diabetics.DJGPhD

26 mins; June 02, 2023

ImmunoEpigenetics 70.Obesity-linked adipose resident macrophage (M1)polarization meta-inflammation leads to Insulin Resistance via fatty acid oxygenation in situ. DJGPhD.01June2023.Authentic Biochem.

29 mins; June 01, 2023

Intermediary Metabolism Lecture. Covalent modification of enzymes and transcription factors alter bioenergetics and the pro-inflammatory response in obese vs. healthy patients.31.5.23 DJGPhD

29 mins; May 31, 2023

See the youtube video in the show notes

1 min; May 26, 2023

ImmunoEpigenetics 69. Lipoprotein and cargo cholesterol in the epigenetic regulation of the tumor microenvironment secreted pleckstrin convertase corrupting CD8+ Tcell cholesterol uptake and potency.

30 mins; May 25, 2023

Graduate Biochemistry Lecture III. Dietary lipid control over neuroendocrine system involves multiple organ systems in contact with immune surveilance. DJGPhD. 24.5.23B Authentic Biochemistry

29 mins; May 24, 2023

Graduate Biochemistry Lecture.II. Lipid digestion and enterocyte localized neuroendocrine secretion proximal to chylomicron assembly.Dr Daniel J. Guerra. Authentic Biochemistry Podcast 19.5.23.

29 mins; May 24, 2023

Special Graduate Biochemistry Lecture! Lipoproteins I. Dr Daniel J. Guerra. Authentic Biochemistry Podcast 19.5.23.

29 mins; May 19, 2023

ImmunoEpigenetics 68. Closure on atherosclerosis and CVD linking transcription factors and membrane receptors to oxidation of PUFA's and oxysterol resulting in methylation of ABCG and SREB promoters

29 mins; May 18, 2023

ImmunoEpigenetics 67. Pathobiochemical alteration of cholesterol oxides mediated via cytochrome P450 and dehydro -reductases link atherosclerosis and the CTX/SLO motor neuron diseases. DJGPhD

29 mins; May 16, 2023

ImmunoEpigenetics 66. The NOX/PHOX/DUOX enzymes in atherosclerosis, thyroid hormonogenesis and thyroid tumorigenesis. An epigenetic telos from oxidized lipid to altered transcription patterns.DJGPhD.

29 mins; May 16, 2023

ImmunoEpigenetics65. 7-keto-cholesterol-induced miR-144 transcription inhibits IDH2 translation lowering NADPH required for NO synthesis to maintain endothelial function leading to atherosclerosis.

30 mins; May 14, 2023

ImmunoEpigenetics65A. Micro-RNA mediated cancellation of mitochondrial NADPH-producing Isocitrate Dehydrogenase 2is controlled by 7-Keto cholesterol. DJGPhD 12May2023. Authentic Biochemistry Podcast

15 mins; May 12, 2023

ImmunoEpigenetics64. IDH1/2 ad Malic enzymes 1/2/3 may generate NADPH thus driving removal of ROS while simultaneously promoting atherosclerosis and tumorigenesis via epigenetic and bioenergetic means

30 mins; May 11, 2023

ImmunoEpigenetics63. Amino acid metabolism is linked to DNA methylation via glycolytic intermediates and redox poise to expose neomorphic /antimorphic IDH1/2 transformation generating oncometabolites

29 mins; May 10, 2023

ImmunoEpigenetics62.Macrophage "training" and T cell activation are epigentically controlled by moonlighting glycolytic and amino acid metabolic enzymes generating enantiomers of 2-OH glutarate.DJGPhD

29 mins; May 09, 2023

ImmunoEpigenetics61. The role of leucocyte and lymphocyte aerobic glycolysis and bioenergetic trafficking between cytosol and the mitochondria mediating nuclear epigenetic substrate availability.

29 mins; May 08, 2023

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